At SM DERMA, our research and development strategy are driven by innovation at the intersection of biotechnology and natural science. We are pioneering next-generation skincare solutions by exploring the synergistic potential of human-derived and plant-derived exosomes.

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Dual-Source Filtration for Purity & Safety

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Dual-Source Filtration for Purity & Safety

- Use advanced ultrafiltration and size-exclusion chromatography to selectively isolate nanosized vesicles (50–150 nm) from both human stem cell conditioned media and plant extracts.
- Combine under strict sterility, ensuring endotoxin-free (human EVs) and pesticide-free (plant EVs).
Application: Medical-grade cosmeceutical serums.

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Sequential Combination Technology

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Sequential Combination Technology

- Use membrane-based microfiltration to separate exosomes by size/charge.
- Layer plant exosomes as an outer “shield” (UV protection, antioxidation) with human exosomes inside (deep repair).
Application: Microneedle patches or hydrogel masks with time-release dual action.

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Customized Ratio Formulation

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Customized Ratio Formulation

• Use filtration-based quantification (NTA, protein/RNA content) to define ratios:
– 70% human EVs + 30% plant EVs (anti-aging focus)
– 50:50 blend (balanced repair + antioxidant)
– 30% human EVs + 70% plant EVs (sensitive skin focus)
Application: Modular serums where customers choose ratios for personal skin needs.

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Cross-Kingdom Cargo Blending

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Cross-Kingdom Cargo Blending

• Engineer filtration to concentrate exosomal RNA/protein cargo from both sources.
• Human EVs deliver pro-collagen & wound-healing factors, while plant EVs provide anti-UV and pigment-regulating signals.
Application: Brightening & repair essence for melasma and photoaging.

Asset 3 scaled

Sequential Combination Technology

View More

Sequential Combination Technology

- Use membrane-based microfiltration to separate exosomes by size/charge.
- Layer plant exosomes as an outer “shield” (UV protection, antioxidation) with human exosomes inside (deep repair).
Application: Microneedle patches or hydrogel masks with time-release dual action.

Asset 5

Cross-Kingdom Cargo Blending

View More

Cross-Kingdom Cargo Blending

• Engineer filtration to concentrate exosomal RNA/protein cargo from both sources.
• Human EVs deliver pro-collagen & wound-healing factors, while plant EVs provide anti-UV and pigment-regulating signals.
Application: Brightening & repair essence for melasma and photoaging.